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KMID : 0378019750180070899
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New Medical Journal
1975 Volume.18 No. 7 p.899 ~ p.906
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Virus LifeParticles found in Hepatocellular Carcinoma
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Abstract
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Electron microscopic examination of the liver was made on 15 cases of primary carcinoma of the liver, and serological tests for HAA and a-fetoprotein were performed by immunodiffusion methods to ascertain whether or not the hepatitis virus has some role in the development of hepatoma. The results were as followings. Among the 15 cases, twelve were hepatocellular carcinomas and two cholangiocarcinomas. The remaining one was mixed type of primary hepatoma. Serum HAA was positive in two cases, both of which were hepatocellular carcinomas. Serum a-fetoprotein was positive in all but two cholangio- and a hepatocellular carcinomas. Electron microscopic examination reveals general ultrastructural chnges usually found in hepatocellular carcinoma, and in 5 cases including that the serum HAA was positive, two kinds of particles which were thought to be similar to that have been known as the Dane particle and smaller particles of about 200-260A in diameter. In three of the five cases the particles were found within vesicular inclusions, which were measured about 3-4u in diameter and were located in cytoplasm or in nucleus. The particles were scattered freely in the cytoplasm without any inclusion in the other two cases. In one that showed intranuclear vesicle, it included some unusual ultrastructure which was considered to be the cytoplasmic organelles.
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